Author

V. V. Edara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 9 Assay:proteomics· 7 Organism:human· 5 Organism:non-human primate· 4 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

L. Lai· 6 shared K. Floyd· 5 shared G. Mantus· 4 shared J. Wrammert· 4 shared R. Ahmed· 4 shared A. Chandele· 3 shared A. Sharma· 3 shared C. W. Davis· 3 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

L. Lai

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

A. Patel, S. Kumar, L. Lai, C. Chakravarthy, R. Valanparambil, E. S. Reddy, K. Gottimukkala, P. Bajpai, D. R. Raju, V. V. Edara, M. E. Davis-Gardner, S. Linderman, K. Dixit, P. Sharma, G. Mantus, , E. A. Ortlund

The paper identifies three monoclonal antibodies that poorly neutralize the Omicron BA.1 variant, revealing structural and molecular features of antibody evasion.

bioRxiv · Oct 24, 2022Immunology

Structural insights for neutralization of BA.1 and BA.2 Omicron variants by a broadly neutralizing SARS-CoV-2 antibody

S. Kumar, A. Patel, L. Lai, C. Chakravarthy, R. Valanparambil, M. E. Davis-Gardner, V. V. Edara, S. Linderman, E. S. Reddy, K. Gottimukkala, K. Nayak, P. Bajpai, V. Singh, F. Frank, N. Cheedarla, , A. Chandele

This paper identifies and structurally analyzes an antibody that neutralizes SARS-CoV-2 BA.1 and BA.2 variants, revealing its unique epitope and mechanism of action.

bioRxiv · May 13, 2022Immunology

Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine

P. S. Arunachalam, Y. Feng, U. Ashraf, M. Hu, V. V. Edara, V. I. Zarnitsyna, P. P. Aye, N. Golden, K. W. M. Green, B. M. Threeton, N. J. Maness, B. J. Beddingfield, R. P. Bohm, J. Dufour, K. Russell-Lodrigue, , B. Pulendran

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

bioRxiv · Mar 18, 2022 · PreprintImmunology

Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates

K. S. Corbett, M. C. Nason, B. Flach, M. Gagne, S. O'Connell, T. S. Johnston, S. N. Shah, V. V. Edara, K. Floyd, L. Lai, C. McDanal, J. R. Francica, B. Flynn, K. Wu, A. Choi, , Leung

This study shows that mRNA-1273 vaccine-induced antibody responses correlate with protection against SARS-CoV-2 infection in nonhuman primates.

bioRxiv · Apr 20, 2021 · PreprintImmunology

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

M. Jennewein, A. MacCamey, N. Akins, J. Feng, L. Homad, N. Hurlburt, E. Seydoux, Y.-H. Wang, A. B. Stuart, V. V. Edara, K. Floyd, A. Vanderheiden, J. R. Mascola, N. Doria-Rose, L. Wang, , L. Stamatatos

The paper isolates and characterizes cross-neutralizing antibodies from COVID-19 patients, identifying antibodies that neutralize both SARS-CoV-1 and SARS-CoV-2, including variants.

bioRxiv · Mar 23, 2021 · PreprintImmunology

Vaccination with SARS-CoV-2 Spike Protein and AS03 Adjuvant Induces Rapid Anamnestic Antibodies in the Lung and Protects Against Virus Challenge in Nonhuman Primates

J. R. Francica, B. J. Flynn, K. E. Foulds, A. T. Noe, A. P. Werner, I. N. Morre, M. Gagne, T. S. Johnston, C. Tucker, R. L. Davis, B. Flach, S. O'Connell, S. F. Andrew, E. Lamb, D. R. Flebbe, , McDermott

This study shows that an AS03-adjuvanted SARS-CoV-2 spike protein vaccine induces strong antibody responses and protects nonhuman primates from viral challenge.

bioRxiv · Mar 2, 2021 · PreprintImmunology

Reduced binding and neutralization of infection- and vaccine-induced antibodies to the B.1.351 (South African) SARS-CoV-2 variant

V. V. Edara, C. Norwood, K. Floyd, L. Lai, M. E. Davis-Gardner, W. H. Hudson, G. Mantus, L. E. Nyhoff, M. W. Adelman, R. Fineman, S. Patel, R. Byram, D. N. Gomes, G. Michael, H. Abdullahi, , M. S. Suthar

The paper compares antibody binding and neutralization against SARS-CoV-2 B.1 and B.1.351 variants in infected and vaccinated individuals, finding reduced titers but retained neutralization.

bioRxiv · Feb 20, 2021 · PreprintImmunology

Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates

P. S Arunachalam, A. C. Walls, N. Golden, C. Atyeo, S. Fischinger, C. Li, P. Aye, M. J. Navarro, L. Lai, V. V. Edara, K. Roltgen, K. Rogers, L. Shirreff, D. E. Ferrell, S. Wrenn, , Coffma

This study evaluates adjuvants for a subunit SARS-CoV-2 nanoparticle vaccine in non-human primates, showing durable neutralizing antibody responses and protection against infection.

bioRxiv · Feb 10, 2021 · PreprintImmunology

Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India

K. Nayak, K. Gottimukkala, S. Kumar, E. S. Reddy, V. V. Edara, R. Kauffman, K. Floyd, G. Mantus, D. Savargaonkar, P. K. Goel, S. Arora, M. Rahi, C. W. Davis, S. Linderman, J. Wrammert, , A. Chandele

This study examines humoral and memory B cell responses in Indian COVID-19 recovered individuals, finding that RBD-specific IgG correlates with neutralizing antibodies and can serve as a surrogate for neutralization assays.

bioRxiv · Aug 31, 2020Immunology