Author

G. Marotta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. T. Baldari· 4 shared A. Onnis· 3 shared C. Cassioli· 3 shared F. Finetti· 3 shared C. Tangredi· 2 shared C. Ulivieri· 2 shared L. Lopresti· 2 shared L. Patrussi· 2 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersImmunology

C. T. Baldari

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Thrombospondins 1 and 4 undergo coordinated transport to multicore cytotoxic granules to regulate SMAP biogenesis and function in CTL-mediatedcytotoxicity

C. Cassioli, N. Capitani, C. C. Staton, C. Schirra, F. Finetti, A. Onnis, N. Alawar, S.-M. Tu, L. Lopresti, V. Tatangelo, C. Tangredi, S. Valvo, H.-F. Chang, A. Miccoli, E. B. Compeer, , C. T. Baldari

This study shows TSP-4 is required for TSP-1 association with lytic granules and SMAP-mediated cytotoxicity in CTLs, and its expression is suppressed in CLL cell supernatants.

bioRxiv · Apr 25, 2024 · PreprintImmunology

Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia

G. Boncompagni, V. Tatangelo, L. Lopresti, C. Ulivieri, N. Capitani, C. Tangredi, F. Finetti, G. Marotta, F. Frezzato, A. Visentin, S. Ciofini, A. Gozzetti, M. Bocchia, D. Calzada-Fraile, N. B. Martin Cofreces, , C. T. Baldari

This study shows that IL-9 secreted by leukemic cells suppresses CTL-mediated killing in CLL by increasing PD-1 expression and impairing immune synapse formation.

bioRxiv · Oct 23, 2023 · PreprintCancer Biology

Polo-like kinase 1 regulates immune synapse assembly and cytotoxic T cell function by driving microtubule dynamics

F. Zevolini, A. Onnis, R. Khazen, S. Mueller, G. Marotta, S. Valiltutti, F. Finetti, C. Baldari

This study shows that Polo-like kinase 1 (PLK1) is essential for immune synapse (IS) assembly and cytotoxic T cell function by regulating microtubule dynamics during IS formation.

bioRxiv · Jul 12, 2023Immunology

Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression

T. Montecchi, G. Nannini, D. De Tommaso, C. Cassioli, F. Coppola, M. N. Rigressi, F. Carraro, A. Naldini, A. Taddei, G. Marotta, A. Amedei, C. T. Baldari, C. Ulivieri

This study identifies Rai as a novel HIF-1-responsive gene upregulated in CRC TILs, which promotes T cell exhaustion by sustaining GSK-3 activation and PD-1 expression.

bioRxiv · Jun 23, 2023Cancer Biology

SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

A. Onnis, E. Andreano, C. Cassioli, E. Pantano, V. Abbiento, G. Marotta, R. Rappuoli, C. T. Baldari

This study shows SARS-CoV-2 Spike protein inhibits CTL immune synapse formation by binding ACE2, reducing target cell killing.

bioRxiv · May 20, 2022Immunology