G. Pepe

Human lncRNAs harbor conserved modules embedded in different sequence contexts

The paper identifies conserved modular exonic regions in human lncRNAs, showing evidence of purifying selection and suggesting functional units similar to protein-coding genes.

Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

This study develops a systems-based strategy to predict drug sensitivity in FLT3-ITD AML by integrating genomic, transcriptomic data with a prior-knowledge signaling network.

NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma

This study identifies a molecular link between Src tyrosine kinase and ferroptosis resistance in glioblastoma through NRF2 pathway activation, suggesting a potential therapeutic target.

Environmental effects on genetic variance are likely to constrain adaptation in novel environments

This study examines how genetic variance in leaf traits changes across elevations in two Sicilian daisy species and finds that environmental effects on genetic variance may limit adaptation in novel environments.

Increased adaptive potential in novel environments can be predicted from genetic variance in development time expressed in native environments

The paper shows that genetic variation in development time in native environments predicts survival in novel environments, with faster development linked to better survival.