Author

G. Schulte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 3 Organism:human· 3 Approach:biophysical modeling· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

H. Schihada· 3 shared P. Kozielewicz· 3 shared C.-F. Bowin· 2 shared L. Graetz· 2 shared M. Kowalski-Jahn· 2 shared A. Turku· 1 shared G. Davidson· 1 shared J. J. Sajkowska-Kozielewicz· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

H. Schihada

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

WNT stimulation induced conformational dynamics in the Frizzled-Dishevelled interaction

C.-F. Bowin, P. Kozielewicz, L. Graetz, M. Kowalski-Jahn, H. Schihada, G. Schulte

The paper analyzes the FZD5-DVL2 interaction to uncover WNT-induced conformational dynamics in a ternary complex.

bioRxiv · Jul 19, 2022 · PreprintPharmacology & Toxicology

Receptor levels determine binding affinity of WNT-3A to Frizzled 7 in a colorectal cancer model

L. Graetz, J. J. Sajkowska-Kozielewicz, J. Wesslowski, K. Petzold, G. Davidson, G. Schulte, P. Kozielewicz

The paper assesses WNT-3A binding affinity to endogenous versus overexpressed FZD7 in colorectal cancer cells and finds lower affinity with higher receptor concentrations.

bioRxiv · Jul 4, 2022Pharmacology & Toxicology

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain.

M. Kowalski-Jahn, H. Schihada, A. Turku, T. Huber, T. P. Sakmar, G. Schulte

The paper develops BRET-based biosensors to study WNT-induced conformational changes in FZD CRD and shows CRD dynamics are not required for WNT/β-catenin signaling.

bioRxiv · May 1, 2021Cell Biology

Quantitative assessment of constitutive G protein-coupled receptor activity with BRET-based G protein biosensors

H. Schihada, R. Shekhani, G. Schulte

The paper validates BRET-based G protein biosensors to quantify constitutive GPCR signaling in living cells.

bioRxiv · Feb 5, 2021Cell Biology

A NanoBRET-based binding assay for Smoothened allows real time analysis of small-molecule ligand binding and distinction of two separate ligand binding sites for BODIPY-cyclopamine

P. Kozielewicz, C.-F. Bowin, G. Schulte

This paper introduces a NanoBRET-based assay for SMO ligand binding, revealing two distinct binding sites for BODIPY-cyclopamine in live cells.

bioRxiv · Jul 19, 2019Pharmacology & Toxicology