Author

P. Kozielewicz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

G. Schulte· 3 shared C.-F. Bowin· 2 shared L. Graetz· 2 shared G. Davidson· 1 shared H. Schihada· 1 shared J. J. Sajkowska-Kozielewicz· 1 shared J. Wesslowski· 1 shared K. Petzold· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

G. Schulte

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintJul 19, 2022

WNT stimulation induced conformational dynamics in the Frizzled-Dishevelled interaction

C.-F. Bowin, P. Kozielewicz, L. Graetz…·G. Schulte

The paper analyzes the FZD5-DVL2 interaction to uncover WNT-induced conformational dynamics in a ternary complex.

DOI 10.1101/2022.07.19.500578

proteomicsbiophysical modeling

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivJul 4, 2022

Receptor levels determine binding affinity of WNT-3A to Frizzled 7 in a colorectal cancer model

L. Graetz, J. J. Sajkowska-Kozielewicz, J. Wesslowski…·P. Kozielewicz

The paper assesses WNT-3A binding affinity to endogenous versus overexpressed FZD7 in colorectal cancer cells and finds lower affinity with higher receptor concentrations.

DOI 10.1111/bph.16090

humanproteomics

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivJul 19, 2019

A NanoBRET-based binding assay for Smoothened allows real time analysis of small-molecule ligand binding and distinction of two separate ligand binding sites for BODIPY-cyclopamine

P. Kozielewicz, C.-F. Bowin, G. Schulte

This paper introduces a NanoBRET-based assay for SMO ligand binding, revealing two distinct binding sites for BODIPY-cyclopamine in live cells.

DOI 10.1124/mol.119.118158

humanproteomics

𝕏 PostBluesky