Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells
O. Guttman, A. Le Thomas, S. A. Marsters, D. A. Lawrence, L. Gutgesell, J. M. Harnoss, S. M. Haag, A. Murthy, G. Strasser, Z. Modrusan, T. Wu, I. Mellman, A. Ashkenazi
The paper shows antigen-derived peptides activate IRE1α in dendritic cells, reducing MHC-I expression and cross-presentation, and demonstrates that IRE1 inhibition enhances anti-tumor immunity.
bioRxiv · Sep 10, 2021Cell Biology