Author

S. M. Haag

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Murthy· 2 shared A. Ashkenazi· 1 shared A. Le Thomas· 1 shared A. Lun· 1 shared A. Nissenbaum· 1 shared B. L. Yaspan· 1 shared C. Cox· 1 shared C. Eidenschenk· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

A. Murthy

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Author profile →

2 papers

Recent·Most cited

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification

S. M. Haag, S. Xie, C. Eidenschenk, J.-P. Fortin, M. Callow, M. Costa, A. Lun, C. Cox, S. Z. Wu, R. N. Pradhan, J. Lock, J. A. Kuhn, L. Holokai, M. Thai, E. Freund, , A. Murthy

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

bioRxiv · Apr 12, 2024 · PreprintImmunology

Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells

O. Guttman, A. Le Thomas, S. A. Marsters, D. A. Lawrence, L. Gutgesell, J. M. Harnoss, S. M. Haag, A. Murthy, G. Strasser, Z. Modrusan, T. Wu, I. Mellman, A. Ashkenazi

The paper shows antigen-derived peptides activate IRE1α in dendritic cells, reducing MHC-I expression and cross-presentation, and demonstrates that IRE1 inhibition enhances anti-tumor immunity.

bioRxiv · Sep 10, 2021Cell Biology