Improving Consistency in Colorectal Cancer Genetic Risk Assessment and Return of Results Through an Integrated Polygenic Risk Score
H. Tran, A. J. Mulford, J. Wei, Z. Shi, A. Ashworth, S. L. Zheng, B. T. Helfand, P. J. Hulick, A. DePersia, G. Suh, B. Jones, A. R. Sanders, Jianfeng Xu
This paper develops a stable polygenic risk score for colorectal cancer by integrating multiple existing scores, improving individual-level risk classification consistency without sacrificing population-level performance.
medRxiv · Nov 9, 2026 · PreprintGenetic & Genomic Medicine