Z. Shi

Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis

This study maps immune cell dynamics during human sequential lymph node metastasis using multi-omics approaches and identifies immune alterations linked to patient survival.

Ultrasound-Driven Programmable Artificial Muscles

This paper introduces programmable artificial muscles using ultrasound-activated microbubbles, achieving high compactness, low weight, and fast response for applications in soft robotics and biomedical devices.

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

Gut-resident C. perfringens impedes rotavirus vaccine efficacy

The paper investigates how gut microbiota, particularly C. perfringens, affects rotavirus vaccine efficacy in mice and human children.

Bola-amphiphilic dendrimer empowers imatinib to target metastatic ovarian cancer stem cells via beta-catenin-HRP2 signaling axis

This study develops a nanoformulation Bola/IM to target metastatic ovarian cancer stem cells via the beta-catenin-HRP2 signaling axis, showing improved efficacy and synergy with cisplatin.

Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages

This study identifies pro-inflammatory macrophages as key regulators of the PE-specific immune microenvironment, linking them to Th17 and CD8+ T cell activation and gMDSC suppression in placental tissues.

Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in Candida glabrata

This study investigates the structural and dynamic organization of plasma membrane proteins in Candida glabrata using cryo-ET and live cell imaging, revealing how echinocandin drugs affect their distribution and function.

Characterization of the SARS-CoV-2 BA.5 Variants in H11-K18-hACE2 Hamsters

This study characterizes SARS-CoV-2 BA.5 variants in H11-K18 hACE2 golden hamsters, showing disease progression and severity similar to human infections, supporting the model's utility for research.

CAMKV Kinase Signaling Is a Novel Therapeutic Avenue with Prognostic Relevance in Neuroblastoma

This study identifies CAMKV kinase signaling as a critical driver of neuroblastoma growth and shows it as a potential therapeutic target and prognostic marker.

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Engineered dimeric and secretory IgA1 neutralized Omicron variants with higher potency than parental IgG.

Alternative splicing expands the antiviral IFITM repertoire in Chinese horseshoe bats

The paper identifies alternative splicing of IFITM genes in Chinese horseshoe bats, producing two isoforms with differential antiviral activities against influenza and coronaviruses.

CSTA: A Biomarker Regulating Esophageal Stricture Epithelial Barrier, Potential Medication Target

The paper identifies CSTA as a biomarker for esophageal epithelial barrier function and shows FK506 can rescue CSTA-knockdown effects in strictures.

Addressing preferred orientation in single-particle cryo-EM through AI-generated auxiliary particles.

This paper introduces cryoPROS, an AI method to address preferred orientation in cryo-EM, improving resolution without special experimental techniques.

Ketone supplementation dampens subjective and objective responses to alcohol in rats and humans

This study shows that ketone supplements reduce alcohol's effects in both humans and rats by lowering blood alcohol levels and altering subjective responses.

Reply to: Contribution of carbon inputs to soil carbon accumulation cannot be neglected

The paper responds to a critique that carbon inputs were neglected in a study on soil carbon storage, arguing that empirical data do not support the critique and that further research is needed.

FOXK2 amplification and overexpression promotes breast cancer development and chemoresistance

This study identifies FOXK2 amplification and overexpression in breast cancer, showing its role in promoting tumor growth, chemoresistance, and synergistic therapeutic responses when targeted with PI3KCA inhibitors.

Overexpression of the violaxanthin de-epoxidase confers faster NPQ and photosynthesis induction in rice

This study shows overexpressing VDE in rice speeds up NPQ and photosynthesis induction, reduces photoinhibition, and increases biomass by 11-16% in field conditions.

Isolation of ACE2-dependent and -independent sarbecoviruses from Chinese horseshoe bats

The paper isolates ACE2-dependent and -independent sarbecoviruses from Chinese horseshoe bats using a new virus isolation protocol.

Nanofluidic Device for Manipulation and Modification of DNA by Proteins

The paper introduces a nanofluidic device that enables real-time combinatorial exchange of buffers and dynamic DNA manipulation to study protein-DNA interactions.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

An e-cigarette aerosol generation, animal exposure and toxicants quantification system to characterize in vivo nicotine kinetics in arterial and venous blood

This paper describes a system for generating and assessing e-cigarette aerosol exposure in animals, showing higher nicotine concentrations in arterial blood compared to venous blood.

DNA capture and loop extrusion dynamics by cohesin-NIPBL

This study uses high-speed AFM to show cohesin-NIPBL captures DNA through arm extension and initiates loop extrusion without ATP hydrolysis, revealing mechanisms of DNA binding and loop formation.

Sirt3 enhanced Bufalin sensitivity of colorectal cancer cells through P53-dependent pathway of apoptosis Sirt3 enhanced Bufalin sensitivity of colorectal cancer cells through P53-dependent pathway of apoptosis

Membrane curvature governs the distribution of Piezo1 in live cells

This study shows membrane curvature regulates Piezo1 distribution in live cells, with Piezo1 depletion from curved protrusions and enrichment in invaginations, and activation reduces filopodia formation.

Pore-forming protein βγ-CAT promptly responses to fasting with capacity to deliver macromolecular nutrients

This study identifies βγ-CAT as a fasting-responsive pore-forming protein that facilitates macromolecular nutrient transport via exosome-mediated uptake in starved muscle cells.

Salidroside protects lipopolysaccharide-induced acute lung injury by regulating miR-145/ cytosolic phospholipase A2

This study shows that salidroside protects against LPS-induced acute lung injury by upregulating miR-145 and suppressing cPLA2 activity.

A pore-forming protein drives macropinocytosis to facilitate toad water maintaining

This study identifies {beta}{gamma}-CAT as a secretory pore-forming protein that drives macropinocytosis and exosome release to aid water uptake in toads under hypertonic stress.

More than just oil droplets in water: surface tension and viscosity of protein condensates quantified by micropipette aspiration

This paper develops a micropipette-based technique to quantify surface tension and viscosity of biomolecular condensates without labeling or surface wetting effects, demonstrating its accuracy with LAF-1 RGG domains and ATPS.

Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor

The paper identifies a novel lineage of SARS-related coronaviruses from bats that use bat ACE2 receptor but not human ACE2, suggesting potential zoonotic risks.