Author

O. S. Kumru

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Organism:mouse· 3 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:non-human primate· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

D. B. Volkin· 4 shared S. B. Joshi· 4 shared H. Kleanthous· 2 shared K. Kaur· 2 shared S. Bajoria· 2 shared B. P. Russ· 1 shared B. Pulendran· 1 shared C. A. Naranjo· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersImmunology

D. B. Volkin

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Author profile →

4 papers

Recent·Most cited

Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor binding domain (RBD)

O. S. Kumru, S. Bajoria, K. Kaur, J. M. Hickey, G. Van Slyke, J. Doering, K. Berman, C. Richardson, H. Lien, H. Kleanthous, N. J. Mantis, S. B. Joshi, D. B. Volkin

This paper evaluates the stability and immunogenicity of a SARS-CoV-2 RBD VLP vaccine candidate formulated with different adjuvants and finds that AP and AH adjuvants provide comparable immunogenicity to AV, with AP showing higher neutralizing titers.

bioRxiv · Jul 10, 2023Immunology

Correlating physicochemical and biological properties to define critical quality attributes of a recombinant AAV vaccine candidate

P. Kumar, M. Wang, O. S. Kumru, J. Hickey, J. Sanmiguel, N. Zabaleta, L. H. Vandenberghe, S. B. Joshi, D. B. Volkin

The paper correlates physicochemical properties of an rAAV vaccine candidate with its biological potency, showing links between physical stability, transduction efficiency, and immunogenicity.

bioRxiv · Mar 10, 2023Immunology

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

P. A.- B. Weidenbacher, M. Sanyal, N. Friedland, S. Tang, P. S Arunachalam, M. Hu, O. S. Kumru, M. K. Morris, J. Fontenot, L. Shirreff, J. Do, Y.-C. Cheng, G. Vasudevan, M. B. Feinberg, F. J. Villinger, , P. S. Kim

This paper describes a ferritin-based nanoparticle vaccine, DCFHP-alum, that induces strong, long-lasting neutralizing antibodies against SARS-CoV-2 variants in non-human primates.

bioRxiv · Dec 25, 2022Immunology

Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants

S. A. Rodriguez-Aponte, N. C. Dalvie, T. Y. Wong, R. S. Johnston, C. A. Naranjo, S. Bajoria, O. S. Kumru, K. Kaur, B. P. Russ, K. S. Lee, H. A. Cyphert, M. Barbier, H. D. Rao, M. P. Rajurkar, R. R. Lothe, , J. C. Love

bioRxiv · Sep 14, 2022Bioengineering