Long-term prevention of aneuploidy in human pluripotent stem cells by fine-tuning GSK3 activity
Anchel De Jaime-Soguero, Mírian Romitti, Sabine Costagliola, Anna Sophia Jauch, G. Vilangappurath, Karl Willert, F. Foijer, S.P. Acebrón
This study shows that low-dose GSK3 inhibitors prevent aneuploidy in hPSCs by reducing mitotic DNA synthesis and ultra-fine chromosome bridges during long-term culture.
bioRxiv · Oct 27, 2025 · PreprintCell Biology