This study shows that low-dose GSK3 inhibitors prevent aneuploidy in hPSCs by reducing mitotic DNA synthesis and ultra-fine chromosome bridges during long-term culture.

bioRxiv · Oct 27, 2025 · PreprintCell Biology

Chemotherapy-treated breast cancer cells activate the Wnt signaling pathway to enter a diapause-DTP state.

Youssef El Laithy, Willy Antoni Abreu De Oliveira, Anirudh Pabba, Alessandra Qualizza, François Richard, Paraskevi Athanasouli, Carla Rios Luci, Wout De Wispelaere, Larissa Mourao, Siân Hamer, Stijn Moens, Anchel De Jaime-Soguero, Maria Francesca Baietti, Stefan J Hutten, Jos Jonkers, , Frederic Lluis

This study shows chemotherapy induces a Wnt-active diapause-DTP state in breast cancer cells, which can be targeted by combined Wnt and chemotherapy inhibition.

bioRxiv · Mar 8, 2024 · PreprintCancer Biology

The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency

Paraskevi Athanasouli, Martina Balli, Anchel De Jaime-Soguero, Annekatrien Boel, Sofia Papanikolaou, Bernard K. van der Veer, Adrian Janiszewski, Tijs Vanhessche, Annick Francis, Youssef El Laithy, Antonio Lo Nigro, Francesco Aulicino, Kian Peng Koh, Vincent Pasque, Maria Pia Cosma, , Frederic Lluı́s

This study shows that Wnt/TCF7L1 repression promotes primitive endoderm differentiation in mESCs by inhibiting naive and formative pluripotency factors.

Nature Communications · Mar 3, 2023Peer-reviewedDevelopmental Biology