This study shows that low-dose GSK3 inhibitors prevent aneuploidy in hPSCs by reducing mitotic DNA synthesis and ultra-fine chromosome bridges during long-term culture.

bioRxiv · Oct 27, 2025 · PreprintCell Biology

Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology

Ilona Lipp, Evgeniya P. Kirilina, C. Jäger, Markus Morawski, Anna Sophia Jauch, Kerrin Pine, L.J. Edwards, Saskia Helbling, D. Rose, Gunther Helms, Cornelius Eichner, Tobias Deschner, Tobias Gräßle, Philipp Gunz, Alfred Anwander, , Nikolaus Weiskopf

This study maps chimpanzee brain development using MRI and histology, finding differences in myelination and iron accumulation compared to humans.

bioRxiv · Dec 6, 2024 · PreprintNeuroscience

Neuroinfectiology of an atypical anthrax-causing pathogen in wild chimpanzees

Tobias Gräßle, Carsten Jäger, Evgeniya P. Kirilina, Jenny E. Jaffe, Penelope Carlier, Andrea Isabel Pizarro, Anna Sophia Jauch, Katja Reimann, Ilona Lipp, Roman Martin Wittig, Catherine Crockford, Nikolaus Weiskopf, Fabian Hubertus Leendertz, Markus Morawski

This study investigates the neuroinfectiology of Bcbva in wild chimpanzees, finding it causes meningitis and breaches the blood-brain barrier more effectively than B. anthracis.

bioRxiv · Nov 21, 2023 · PreprintNeuroscience

A versatile system to introduce clusters of genomic double-strand breaks in large cell populations

Thorsten Kolb, Umar Khalid, Milena Simovic-Lorenz, Manasi Ratnaparkhe, John Wong, Anna Sophia Jauch, Peter Schmezer, Agata Rode, Shulamit Sebban, Daniel Haag, Michaela Hergt, Frauke Devens, Yosef Buganim, Marc Zapatka, Peter Lichter, Aurélie Ernst

This paper introduces a method to generate localized DNA double-strand breaks in cell populations using UV-irradiation with photomasks, enabling the study of genome rearrangements and DNA damage response.

Genes Chromosomes and Cancer · Jul 31, 2020Peer-reviewedGenomics