SARS-CoV-2 Defective Viral Genomes from Distinct Genomic Regions Drive Divergent Interferon Responses
Justin W Brennan, Simone Spandau, Jiayu Xu, Xingjian Wang, Haley G. Aull, G.C. Wang, Sarah Connor, Gloria Pryhuber, Thomas J. Mariani, Ruth Serra-Moreno, Susan Reich Weiss, Yan Sun
This study shows that SARS-CoV-2 defective viral genomes from different genomic hotspots induce divergent interferon responses, with hotspot B DVGs strongly stimulating IFN responses and hotspot A DVGs not.
PLoS Pathogens · Sep 23, 2026Peer-reviewedMicrobiology