Susan Reich Weiss

SARS-CoV-2 Defective Viral Genomes from Distinct Genomic Regions Drive Divergent Interferon Responses

This study shows that SARS-CoV-2 defective viral genomes from different genomic hotspots induce divergent interferon responses, with hotspot B DVGs strongly stimulating IFN responses and hotspot A DVGs not.

Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants

This study shows adenovirus mutants differentially activate dsRNA sensors, leading to distinct RNP granule assemblies via PKR and OAS3/RNase L pathways.

Inhibition of RNA splicing is a novel therapeutic strategy for disruption of nuclear replicating viruses

This study shows that inhibiting RNA splicing reduces viral replication in splicing-dependent viruses like adenovirus, HSV-1, and influenza A, suggesting a new antiviral strategy.

Evaluating Spike Antigenicity across Endemic Human Coronavirus Models using Flow Virometry

This study uses flow virometry to analyze spike antigenicity of endemic human coronaviruses, revealing cell line-dependent differences and heterogeneity not captured by bulk assays.

SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response

This study compares how SARS-CoV-2 and MERS-CoV nsp1 proteins affect host protein synthesis and the integrated stress response, revealing differential impacts on eIF2 phosphorylation and stress granule formation.

Clade C MERS-CoV camel strains vary in protease utilizationduring viral entry

This study compares protease utilization in Clade C MERS-CoV camel strains, finding reduced TMPRSS2-mediated entry in East African isolates compared to Clade A/B strains.

MERS-CoV antagonizes PKR activation by inhibiting its condensation at viral replication complexes

This study shows MERS-CoV inhibits PKR activation by blocking its condensation on viral dsRNA, revealing a mechanism by which the virus evades innate immune responses.

Betacoronaviruses Differentially Activate the Integrated Stress Response to Optimize Viral Replication in Lung Derived Cell Lines

This study compares how three betacoronaviruses interact with the PERK pathway of the integrated stress response, showing differences in their reliance on eIF2 dephosphorylation for replication.

SARS-CoV-2 ORF8 encoded protein contains a histone mimic, disrupts chromatin regulation, and enhances replication