Alpha cell inflammation during human pancreas aging and type 2 diabetes and its reversal by calorie restriction in mice.
Michael W. Schleh, Jeeyeon Cha, Shristi Shrestha, Amanda Cambraia, Aliyah Habashy, Cara E. Ellis, Melanie Cutler, Gabriel Ferguson, Alvin C. Powers, Rafael Arrojo e Drigo
The paper identifies an inflammatory phenotype in aging human alpha cells and shows calorie restriction reduces inflammation in mice.
bioRxiv · Jun 4, 2025 · PreprintPhysiology