Cara E. Ellis

This study compares functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in high and low insulin production states, revealing differences in resilience and protein machinery.

This study compares immature stem-cell-derived β-cells to primary β-cells using multi-omic single-cell methods, identifying SREBP1 as a target for improving β-cell maturation.

The paper identifies an inflammatory phenotype in aging human alpha cells and shows calorie restriction reduces inflammation in mice.

This study investigates GlyR dysfunction in T2D and high glucose conditions, finding reduced GlyR currents and gene expression, but no splicing changes, and links GlyR activity to gene regulatory networks.

This study investigates islet cell dysfunction in type 1 diabetes by integrating electrophysiological, transcriptomic, and machine learning analyses of human islet cells from T1D donors.

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

The paper integrates single-cell multiomic data with genetics to identify gene regulatory changes in beta cells associated with type 2 diabetes.