Author

Melanie Cutler

Vanderbilt University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Amanda CambraiaiD· 3 shared Rafael Arrojo e DrigoiD· 3 shared Aliyah Habashy· 2 shared Cristiane dos SantosiD· 2 shared Jean Philippe CartailleriD· 2 shared Michael W. SchlehiD· 2 shared Alvin C. PowersiD· 1 shared Cara E. EllisiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCell Biology

Amanda CambraiaORCID

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3 papers

Recent·Most cited

Calorie Restriction modulates beta cell IP3R activity to regulate Ca2+ homeostasis and cell network connectivity

Johannes U. Pfabe, Amanda Cambraia, Prasanna K. Dadi, Melanie Cutler, Cristiane dos Santos, Christopher Acree, Aliyah Habashy, Guy A Perkins, Mark H. Ellisman, David Aaron Jacobson, Marjan Slak Rupnik, Rafael Arrojo e Drigo

This study investigates how calorie restriction modulates beta cell Ca2+ homeostasis and network connectivity, finding that CR beta cells exhibit faster, shorter Ca2+ oscillations and reduced network connectivity.

Cell Calcium · Jun 18, 2026Peer-reviewedCell Biology

Calorie Restriction Up-regulates Islet PD-L1 Signaling and Decreases the Risk of Auto-immune Diabetes Onset in NOD Mice.

Amanda Cambraia, Michael W. Schleh, Jean Philippe Cartailler, Melanie Cutler, Cristiane dos Santos, Gina M. Many, Hyeyoon Kim, Young‐Mo Kim, Ernesto Satoshi Nakayasu, Denis A. Mogilenko, Rafael Arrojo e Drigo

This study shows calorie restriction delays type 1 diabetes onset in NOD mice by enhancing glucose homeostasis and promoting a pro-tolerogenic islet microenvironment through increased PD-L1 expression.

bioRxiv · Feb 17, 2026 · PreprintCell Biology

Alpha cell inflammation during human pancreas aging and type 2 diabetes and its reversal by calorie restriction in mice.

Michael W. Schleh, Jeeyeon Cha, Shristi Shrestha, Amanda Cambraia, Aliyah Habashy, Cara E. Ellis, Melanie Cutler, Gabriel Ferguson, Alvin C. Powers, Rafael Arrojo e Drigo

The paper identifies an inflammatory phenotype in aging human alpha cells and shows calorie restriction reduces inflammation in mice.

bioRxiv · Jun 4, 2025 · PreprintPhysiology