Michael W. Schleh

This study shows calorie restriction delays type 1 diabetes onset in NOD mice by enhancing glucose homeostasis and promoting a pro-tolerogenic islet microenvironment through increased PD-L1 expression.

The paper identifies an inflammatory phenotype in aging human alpha cells and shows calorie restriction reduces inflammation in mice.

This study identifies reduced insulin-mediated suppression of fatty acid release and altered skeletal muscle lipid droplet characteristics as predictors of insulin resistance in adults with obesity.

This study shows that CD163 deficiency in obese male mice worsens insulin sensitivity by promoting inflammation and iron dysregulation in adipose tissue macrophages.