Amanda Cambraia

This study investigates how calorie restriction modulates beta cell Ca2+ homeostasis and network connectivity, finding that CR beta cells exhibit faster, shorter Ca2+ oscillations and reduced network connectivity.

This study shows calorie restriction delays type 1 diabetes onset in NOD mice by enhancing glucose homeostasis and promoting a pro-tolerogenic islet microenvironment through increased PD-L1 expression.

The paper identifies an inflammatory phenotype in aging human alpha cells and shows calorie restriction reduces inflammation in mice.