Biotin rescues manganese-induced Parkinson's disease phenotypes and neurotoxicity
Yunjia Lai, Pablo Reina-Gonzalez, Gali Maor, Gary Wright Miller, Souvarish Sarkar
This study identifies biotin pathway dysregulation as a key mechanism linking manganese toxicity to Parkinson's disease using Drosophila and human iPSC models, showing biotin supplementation rescues neurotoxic phenotypes.
bioRxiv · Nov 21, 2023 · PreprintNeuroscience