Development of a PC12 cell-based assay for in vitro screening of catechol-O-methyltransferase inhibitors
Gongliang Zhang, Ingrid P. Buchler, Michael J. Depasquale, Michael Wormald, Gangling Liao, Huijun Wei, James C. Barrow, Gregory V. Carr
This study evaluates the use of PC12 cells as an in vitro platform to screen COMT inhibitors, showing that tolcapone and LIBD-3 increase dopamine and DOPAC while reducing 3-MT and HVA.
ACS Chemical Neuroscience · Sep 6, 2019Peer-reviewedNeuroscience