Author

Michael J. Depasquale

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:rat· 2

Frequent Co-Authors

Gongliang ZhangiD· 2 shared Gregory V. CarriD· 2 shared Huijun WeiiD· 2 shared Ingrid P. Buchler· 2 shared James C. BarrowiD· 2 shared Anna Kolobova· 1 shared Cailian LiiD· 1 shared Daniel AkumaiD· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Gongliang ZhangORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Novel, non-nitrocatechol COMT inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility

Spencer Byers, Ingrid P. Buchler, Michael J. Depasquale, Helen L. Rowley, Rajiv S. Kulkarni, Lucy Pinder, Anna Kolobova, Cailian Li, Vinh Au, Daniel Akuma, Gongliang Zhang, Huijun Wei, Sharon C. Cheetham, James C. Barrow, Gregory V. Carr

The paper identifies novel COMT inhibitors that improve cognitive flexibility in rats by modulating dopamine metabolites in the frontal cortex and cerebrospinal fluid.

Psychopharmacology · May 30, 2020Peer-reviewedNeuroscience

Development of a PC12 cell-based assay for in vitro screening of catechol-O-methyltransferase inhibitors

Gongliang Zhang, Ingrid P. Buchler, Michael J. Depasquale, Michael Wormald, Gangling Liao, Huijun Wei, James C. Barrow, Gregory V. Carr

This study evaluates the use of PC12 cells as an in vitro platform to screen COMT inhibitors, showing that tolcapone and LIBD-3 increase dopamine and DOPAC while reducing 3-MT and HVA.

ACS Chemical Neuroscience · Sep 6, 2019Peer-reviewedNeuroscience