Redox Regulation of m6A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes
Dario F. De Jesus, Zijie Scott Zhang, Natalie K. Brown, Xiaolu Li, Ling Xiao, Jiang Yong Hu, Matthew J. Gaffrey, Garrett Fogarty, Sevim Kahraman, Jiangbo Wei, Giorgio Basile, Tariq M. Rana, Clayton E. Mathews, Alvin C. Powers, Audrey V. Parent, , Rohit Kulkarni
This study shows that m6A methylation, regulated by METTL3, controls the innate immune response in β-cells during T1D onset by modulating OAS mRNA stability.
Nature Cell Biology · Feb 26, 2024Peer-reviewedMolecular Biology