Degron-based bioPROTACs for controlling signaling in CAR T cells
Matthew S. Kim, Hersh K. Bhargava, Gavin E. Shavey, Wendell A. Lim, Hana El‐Samad, Andrew H. Ng
This paper introduces bioPROTACs, a genetic tool to control CAR T cell signaling by degrading specific proteins, demonstrating its effectiveness in inhibiting CAR signaling in human T cells.
ACS Synthetic Biology · Jul 11, 2024Peer-reviewedSynthetic Biology