Hersh K. Bhargava

Degron-based bioPROTACs for controlling signaling in CAR T cells

This paper introduces bioPROTACs, a genetic tool to control CAR T cell signaling by degrading specific proteins, demonstrating its effectiveness in inhibiting CAR signaling in human T cells.

Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning

The paper uses synthetic costimulatory domains and machine learning to identify design rules for CARs that enhance cytotoxicity and stemness.

Bright and tunable far-red chemigenetic indicators

The paper introduces a new platform for chemigenetic fluorescent indicators with bright, far-red emission and tunable properties for detecting single action potentials in neurons.

An Interscholastic Network to Generate LexA Enhancer Trap Lines in Drosophila

The paper describes the generation and characterization of novel LexA enhancer trap lines in Drosophila through a collaborative interscholastic network.