Author
University of California, San FranciscoORCID 0000-0001-8044-1807Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Rajini Srinivasan, Tao Sun, Azalia Sandles, Diana H. Wu, Liang Wang, Hetal Patel, Ryan Pabalate, Maram Bader, Amy J. Heidersbach, Clark Ho, Shiqi Xie, Andrew H. Ng, Benjamin Haley
This paper develops inducible CRISPR/Cas9 systems with improved dynamic range and reduced off-target effects for precise gene perturbation.
Nature Communications · Dec 12, 2025Peer-reviewedMolecular Biology
Matthew S. Kim, Hersh K. Bhargava, Gavin E. Shavey, Wendell A. Lim, Hana El‐Samad, Andrew H. Ng
This paper introduces bioPROTACs, a genetic tool to control CAR T cell signaling by degrading specific proteins, demonstrating its effectiveness in inhibiting CAR signaling in human T cells.
ACS Synthetic Biology · Jul 11, 2024Peer-reviewedSynthetic Biology
Susan Y. Chen, Lindsey C. Osimiri, Michael W. Chevalier, Lukasz J. Bugaj, Taylor H. Nguyen, R.A. Greenstein, Andrew H. Ng, Jacob Stewart-Ornstein, Lauren T. Neves, Hana El‐Samad
The paper introduces CLASP, an optogenetic tool to control TF localization, and shows differential promoter responses to pulsatile vs. continuous TF inputs.
Cell Systems · Sep 7, 2020Peer-reviewedSystems Biology
Galen Dods, Mariana Gómez-Schiavon, Hana El‐Samad, Andrew H. Ng
The paper shows that accurate prediction of genetic circuit behavior requires multidimensional characterization of parts, using computational models and experimental verification.
bioRxiv · May 30, 2020 · PreprintSynthetic Biology
João Pedro Fonseca, Alain R. Bonny, G. Renuka Kumar, Andrew H. Ng, Jason P. Town, Qiu Chang Wu, Elham Aslankoohi, Susan Y. Chen, Galen Dods, Patrick Harrigan, Lindsey C. Osimiri, Amy L. Kistler, Hana El‐Samad
The paper introduces MTK, a toolkit for rapid modular DNA circuit assembly in mammalian cells, demonstrating its use in constructing an Ebola virus replication complex circuit.
ACS Synthetic Biology · Nov 5, 2019Peer-reviewedSynthetic Biology
Michael W. Chevalier, Mariana Gómez-Schiavon, Andrew H. Ng, Hana El‐Samad
This paper designs and analyzes a biochemical PID controller using biological molecules, showing improved performance through computational and analytical methods.
Cell Systems · Sep 25, 2019Peer-reviewedSynthetic Biology
Kale Kundert, James E. Lucas, Kyle E. Watters, Christof Fellmann, Andrew H. Ng, Benjamin Murray Heineike, Christina M. Fitzsimmons, Benjamin L. Oakes, Jiuxin Qu, Neha K. Prasad, Oren S. Rosenberg, David F. Savage, Hana El‐Samad, Jennifer A. Doudna, Tanja Kortemme
Inserting theophylline aptamers into the sgRNA yields ligand-activated and ligand-deactivated guides that tune CRISPRi in E. coli over 11x to 13x dynamic ranges, enabling two-ligand multiplexing.
Nature Communications · May 9, 2019Peer-reviewedSynthetic Biology✦ In-depth digest
Enoch Yeung, Aaron J. Dy, Kyle B. Martin, Andrew H. Ng, Domitilla Del Vecchio, James L. Beck, James J. Collins, Richard M. Murray
This study shows that compositional context in synthetic gene networks significantly affects gene expression levels and key regulatory properties.
bioRxiv · Nov 30, 2016 · PreprintSynthetic Biology