Random mutagenesis of influenza hemagglutinin identifies new sites which modulate its acid-stability and cleavability
Silke Rimaux, M.F. Oliva, Cato Mestdagh, Ria Van Berwaer, Jianjun Chen, Geert Schoofs, Bert Vanmechelen, Joren Stroobants, Maarten Jacquemyn, M. Laporte, Piet Maes, Kurt Vermeire, Kalyan Das, Annelies Stevaert, Lieve M. J. Naesens
This study identifies mutations in influenza hemagglutinin that increase acid-stability and decrease cleavability, with implications for viral transmissibility and vaccine development.
bioRxiv · Jul 25, 2025 · PreprintMicrobiology