Author

Ria Van Berwaer

Rega Institute for Medical Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

Annelies StevaertiD· 4 shared Lieve M. J. NaesensiD· 4 shared Bert VanmecheleniD· 3 shared Cato MestdaghiD· 3 shared Piet MaesiD· 3 shared Benjamin Van LoyiD· 2 shared Celia EscricheiD· 2 shared Juan Martín-López· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

Annelies StevaertORCID

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4 papers

Recent·Most cited

Mechanistic insights into coronavirus inhibition by a distinct base-modified adenosine analog targeting the viral polymerase

Nikolai Bakirtzoglou, Barbara Selisko, Yucen Huang, Peng Nie, Bruno Ribeiro de Castro Ramos, Ria Van Berwaer, Lieselotte Schurmans, Véronique Fattorini, Yu Zhou, Yufan Pan, Xiaoxia An, Julie Vandeput, Benjamin Van Loy, Bert Vanmechelen, Piet Maes, , Annelies Stevaert

This paper investigates the mechanism of 6-ethyl-modified 7-deazaadenosine (EDA) as a coronavirus inhibitor, showing it stalls viral polymerase without causing mutagenesis.

bioRxiv · Oct 29, 2026 · PreprintMicrobiology

N-benzamides as Influenza Virus Fusion Inhibitors Acting on H1 and H5 Hemagglutinins

Silke Rimaux, Aitor Valdivia, Juan Martín-López, Valeria Francesconi, Celia Escriche, Cato Mestdagh, Ria Van Berwaer, Lieselotte Schurmans, Kaat Verleye, Sam Noppen, Oscar Perlaza Lozano, Annelies Stevaert, Francisco Javier Luque, Lieve M. J. Naesens, Santiago Vázquez

This paper identifies N-benzamides as inhibitors of influenza virus fusion, showing efficacy against H1 and H5 hemagglutinins with low EC50 values and high selectivity.

bioRxiv · Jul 28, 2025 · PreprintMicrobiology

Random mutagenesis of influenza hemagglutinin identifies new sites which modulate its acid-stability and cleavability

Silke Rimaux, M.F. Oliva, Cato Mestdagh, Ria Van Berwaer, Jianjun Chen, Geert Schoofs, Bert Vanmechelen, Joren Stroobants, Maarten Jacquemyn, M. Laporte, Piet Maes, Kurt Vermeire, Kalyan Das, Annelies Stevaert, Lieve M. J. Naesens

This study identifies mutations in influenza hemagglutinin that increase acid-stability and decrease cleavability, with implications for viral transmissibility and vaccine development.

bioRxiv · Jul 25, 2025 · PreprintMicrobiology

A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses

Benjamin Van Loy, Eugènia Pujol, Kenichi Kamata, Xiao Yin Lee, Nikolai Bakirtzoglou, Ria Van Berwaer, Julie Vandeput, Cato Mestdagh, Leentje Persoons, Brent De Wijngaert, Quinten Goovaerts, Sam Noppen, Maarten Jacquemyn, Kourosh Ahmadzadeh, Eline Bernaerts, , Annelies Stevaert

This paper identifies EPB-113, a guanidine-based inhibitor of coronavirus nsp15 endoribonuclease, which suppresses viral replication and selects for interferon-susceptible mutants.

PLoS Pathogens · Feb 11, 2025Peer-reviewedMicrobiology