Author

Cato Mestdagh

KU LeuvenORCID 0000-0002-4068-4975Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:virus· 1

Frequent Co-Authors

Lieve M. J. NaesensiD· 4 shared Annelies StevaertiD· 3 shared Ria Van Berwaer· 3 shared Bert VanmecheleniD· 2 shared Celia EscricheiD· 2 shared Juan Martín-López· 2 shared Kalyan DasiD· 2 shared Maarten JacquemyniD· 2 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

Lieve M. J. NaesensORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

N-benzamides as Influenza Virus Fusion Inhibitors Acting on H1 and H5 Hemagglutinins

Silke Rimaux, Aitor Valdivia, Juan Martín-López, Valeria Francesconi, Celia Escriche, Cato Mestdagh, Ria Van Berwaer, Lieselotte Schurmans, Kaat Verleye, Sam Noppen, Oscar Perlaza Lozano, Annelies Stevaert, Francisco Javier Luque, Lieve M. J. Naesens, Santiago Vázquez

This paper identifies N-benzamides as inhibitors of influenza virus fusion, showing efficacy against H1 and H5 hemagglutinins with low EC50 values and high selectivity.

bioRxiv · Jul 28, 2025 · PreprintMicrobiology

Random mutagenesis of influenza hemagglutinin identifies new sites which modulate its acid-stability and cleavability

Silke Rimaux, M.F. Oliva, Cato Mestdagh, Ria Van Berwaer, Jianjun Chen, Geert Schoofs, Bert Vanmechelen, Joren Stroobants, Maarten Jacquemyn, M. Laporte, Piet Maes, Kurt Vermeire, Kalyan Das, Annelies Stevaert, Lieve M. J. Naesens

This study identifies mutations in influenza hemagglutinin that increase acid-stability and decrease cleavability, with implications for viral transmissibility and vaccine development.

bioRxiv · Jul 25, 2025 · PreprintMicrobiology

Antiviral Mechanisms and Preclinical Evaluation of Amantadine Analogs that Continue to Inhibit Influenza A Viruses with M2 S31N-Based Drug Resistance

Ian Tietjen, Daniel Kwan, Annett Petrich, Roland Zell, Ivi Theodosia Antoniadou, Agni F. M. Gavriilidou, Christina Tzitzoglaki, Michail Christou Rallis, David Fedida, Francesc Xavier Sureda, Cato Mestdagh, Lieve M. J. Naesens, Salvatore Chiantia, F. Brent Johnson, Antonios Kolocouris

This study evaluates amantadine analogs against influenza A viruses with M2S31N resistance, finding some inhibit viral entry and assembly while being tolerated in mice.

Antiviral Research · Feb 11, 2025Peer-reviewedMicrobiology

A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses

Benjamin Van Loy, Eugènia Pujol, Kenichi Kamata, Xiao Yin Lee, Nikolai Bakirtzoglou, Ria Van Berwaer, Julie Vandeput, Cato Mestdagh, Leentje Persoons, Brent De Wijngaert, Quinten Goovaerts, Sam Noppen, Maarten Jacquemyn, Kourosh Ahmadzadeh, Eline Bernaerts, , Annelies Stevaert

This paper identifies EPB-113, a guanidine-based inhibitor of coronavirus nsp15 endoribonuclease, which suppresses viral replication and selects for interferon-susceptible mutants.

PLoS Pathogens · Feb 11, 2025Peer-reviewedMicrobiology