Ovarian extracellular matrix mechanics regulate oocyte-follicle interactions during female reproductive aging
Xingyu Shen, Hao Wang, Gefei Cao, Yaelim Lee, Jin Zhu, Loo Chien Wang, Tianyun Zhao, Siok Ghee Ler, Radoslaw M. Sobota, Rong Li, Jennifer L. Young
This study shows that increased ovarian ECM stiffness with age impairs follicle function by reducing granulosa cell proliferation and oocyte quality through TGF-β signaling.
Aging Cell · Aug 1, 2026Peer-reviewedCell Biology