Structural basis of context-dependent RORγt target gene activation on chromatin
Timothy S. Strutzenberg, Xiandu Li, Matthew D. Mann, Hye Jeong Shin, J. McCulley Kelsey, Sriram Aiyer, Samuel M. Cotsarelis, Jingting Yu, Gennavieve Gray, Zelin Shan, George Wanes, Bo Zhou, Ronald M. Evans, Paul C. Whitford, Patrick R. Griffin, , Dmitry Lyumkis
This study identifies how RORγt mutations affect gene activation by altering chromatin binding modes, explaining context-dependent autoimmunity and host defense outcomes.
bioRxiv · Mar 10, 2025 · PreprintBiophysics