Ronald M. Evans

Chronic pancreatitis patient-derived organoids reveal new paths to precision therapeutics

This study uses patient-derived organoids to identify CFTR modulators as a therapeutic strategy for chronic pancreatitis.

HDAC Inhibition Sensitizes Pancreatic Tumors to DNA Damage by Global Redistribution of the Transcriptional Machinery

This study shows HDAC inhibition reduces DDR gene expression in pancreatic tumors by altering transcriptional machinery distribution, enhancing sensitivity to DNA damage, and introduces a nanoparticle delivery system to reduce toxicity.

CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma

This study identifies CA19-9's role in remodeling the PDAC tumor microenvironment by inducing IL1a and TGFb, leading to immunosuppressive changes that can be mitigated by blocking these factors.

CA19-9 promotes liver metastasis of pancreatic cancer through E-selectin mediated extravasation

This study shows CA19-9 promotes pancreatic cancer liver metastasis via E-selectin-mediated extravasation and AKT signaling, suggesting it as a therapeutic target.

Structural basis of context-dependent RORγt target gene activation on chromatin

This study identifies how RORγt mutations affect gene activation by altering chromatin binding modes, explaining context-dependent autoimmunity and host defense outcomes.

Neural basis of opioid-induced respiratory depression and its rescue

This study identifies PBLOprm1 neurons as critical for opioid-induced respiratory depression and shows their activation can rescue respiratory rhythms.

Unified neural pathways that gate affective pain and multisensory innate threat signals to the amygdala

The paper identifies unified neural pathways that gate affective pain and multisensory innate threat signals to the amygdala, revealing their role in aversive perception.