Author

Matthew D. Mann

Salk Institute for Biological StudiesORCID 0000-0002-4474-4592Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Patrick R. GriffiniD· 2 shared Anna MalovannayaiD· 1 shared Antrix JainiD· 1 shared Bo ZhouiD· 1 shared Bruce D. PascaliD· 1 shared Dean P. Edwards· 1 shared Dmitry LyumkisiD· 1 shared Gennavieve Gray· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Patrick R. GriffinORCID

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2 papers

Recent·Most cited

Structural proteomics defines a sequential priming mechanism for the progesterone receptor

Matthew D. Mann, Min Wang, Josephine C. Ferreon, Phoebe S. Tsoi, Michael P. Suess, Antrix Jain, Anna Malovannaya, Roberto Vera Alvarez, Bruce D. Pascal, Praveen Kumar, Dean P. Edwards, Patrick R. Griffin

This study uses structural mass spectrometry to reveal the sequential binding mechanism of progesterone receptor isoforms with co-regulatory proteins on target DNA.

Nature Communications · May 12, 2025Peer-reviewedBiochemistry

Structural basis of context-dependent RORγt target gene activation on chromatin

Timothy S. Strutzenberg, Xiandu Li, Matthew D. Mann, Hye Jeong Shin, J. McCulley Kelsey, Sriram Aiyer, Samuel M. Cotsarelis, Jingting Yu, Gennavieve Gray, Zelin Shan, George Wanes, Bo Zhou, Ronald M. Evans, Paul C. Whitford, Patrick R. Griffin, , Dmitry Lyumkis

This study identifies how RORγt mutations affect gene activation by altering chromatin binding modes, explaining context-dependent autoimmunity and host defense outcomes.

bioRxiv · Mar 10, 2025 · PreprintBiophysics