CAR T cell cytotoxic responses are rapidly generated and sensitive to the unligated TCR
Kevin L. Scrudders, Suriya Selvarajan, Kenneth Rodriguez-Lopez, Weichuan Luo, Bo Huang, Suilan Zheng, Geoffrey H. Graff, Francisco N. Barrera, Philip Stewart Low, Shalini T. Low-Nam
This study investigates CAR T cell cytotoxic responses, showing they are sensitive to TCR interactions and can be modulated by inhibitory peptides.
bioRxiv · Jul 25, 2025 · PreprintImmunology