The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process.
Marlène Magalhaes Pinto, Bert Malengier‐Devlies, Guillaume Seuzaret, Anna Ahlback, Solvig Becker, Katelyn Patatsos, Georgios Drakoulis, Julia Karjalainen, Christiane Ruedl, David Voehringer, Calum C. Bain, Elaine Emmerson, Barbora Schonfeldova, Kristina Zec, Irina A. Udalova, , Rebecca Gentek
The paper identifies CSF1 and TGFβ as key signals for synovial lining macrophage development in mice, which occurs postnatally and is monocyte-independent.
bioRxiv · May 21, 2025 · PreprintImmunology