Protein context shapes the specificity of domain-peptide interactions in vivo
Ugo Dionne, Émilie Bourgault, Alexandre K. Dubé, David T. Carreon Bradley, François J.-M. Chartier, Rohan Dandage, Soham Dibyachintan, Philippe C Després, Gerald D. Gish, Jean‐Philippe Lambert, Nicolas Bisson, Christian R. Landry
The paper shows that SH3 domain specificity in PPIs is influenced by host protein identity and domain position, not just intrinsic domain properties.
bioRxiv · May 18, 2020 · PreprintSystems Biology