Author

Karen Colwill

Lunenfeld-Tanenbaum Research InstituteORCID 0000-0002-8979-1659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Anne‐Claude GingrasiD· 2 shared Adrian Pasculescu· 1 shared Allison McGeeriD· 1 shared Alyson Takaoka· 1 shared Andreas O. Helbig· 1 shared Anjali PateliD· 1 shared Brett G. Larsen· 1 shared Cassandra J. WongiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

Anne‐Claude GingrasORCID

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3 papers

Recent·Most cited

mRNA Vaccine-Induced SARS-CoV-2 Spike-Specific IFN-γ and IL-2 T-cell Responses are Predictive of Serological Neutralization and are Transiently Enhanced by Pre-Existing Cross-Reactive Immunity

Philip Samaan, Chapin S. Korosec, Patrick Budylowski, S. L. L. Chau, Adrian Pasculescu, Freda Qi, Melanie Delgado-Brand, Tulunay R. Tursun, Geneviève Mailhot, Roya Monica Dayam, Corey R. Arnold, Marc‐André Langlois, Justin Mendoza, Thomas Morningstar, Ryan Law, , Mario Ostrowski

This study examines how mRNA vaccine-induced T-cell responses correlate with neutralizing antibodies and how pre-existing immunity affects vaccine responses over time.

Journal of Virology · Jan 31, 2025Peer-reviewedImmunology

Mapping Protein-Protein Interactions Using Data-Dependent Acquisition Without Dynamic Exclusion

Shen Zhang, Brett G. Larsen, Karen Colwill, Cassandra J. Wong, Ji‐Young Youn, Anne‐Claude Gingras

The paper compares noDE and DDA/DIA methods for protein-protein interaction detection, finding noDE provides better sensitivity and identifies more high confident interactors.

Analytical Chemistry · Jul 18, 2022Peer-reviewedSystems Biology

Decoding the functional Fes kinase signaling network topology in a lymphocyte model

Andreas O. Helbig, Michael Kofler, Gerald D. Gish, Lourdes Sriraja, Kristina Lorenzen, Monika Tucholska, Cunjie Zhang, Frederick P. Roth, Tony J. Pawson, Karen Colwill, Evangelia Petsalaki

The paper identifies c-Fes kinase substrates and shows how c-Fes and Src signaling balance regulates CD19 levels and influences B-cell receptor signaling.

bioRxiv · Apr 29, 2020 · PreprintSystems Biology