A TAK1-Driven NLRP1 Inflammasome Pathway Revealed by Phosphatase-Targeting Environmental Toxins
M. Paradis, Léana Gorse, Leandro Silva da Costa, Rae Chua, Geraldine Aberola, Arnaud Métais, Ludovic Batistic, Thomas Benoist, Anthony David, Emeline Pagès, Andrea Gomes, Caio César Barbosa Bomfim, Léa Ravon‐Katossky, Bastien Suire, Léa Fromont, , Étienne Meunier
The paper identifies PP1 and PP2A phosphatases as regulators of NLRP1 inflammasome activation, showing that environmental toxins and viral infections trigger this pathway via TAK1 and p38 kinases.
bioRxiv · Jan 25, 2026 · PreprintImmunology