Arnaud Métais

Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapies

This study uses dual human lung models to evaluate anti-tuberculosis drugs and host-directed therapies, revealing compartment-specific efficacy and immune responses.

A TAK1-Driven NLRP1 Inflammasome Pathway Revealed by Phosphatase-Targeting Environmental Toxins

The paper identifies PP1 and PP2A phosphatases as regulators of NLRP1 inflammasome activation, showing that environmental toxins and viral infections trigger this pathway via TAK1 and p38 kinases.

Moesin controls cell-cell fusion and osteoclast function

This study identifies moesin's role in osteoclast fusion and function, showing its impact on bone resorption and disease therapy.

Lipid-mediated GPR32 signaling reprograms macrophage metabolism to impair anti-tuberculous immunity

The paper identifies RvD5-GPR32 signaling as a mechanism by which TB-PE reprograms macrophage metabolism to impair anti-tuberculous immunity.

Identification of a unique TUBB3+ cell population in the tuberculosis granuloma

The paper identifies a TUBB3+ cell population in TB granulomas across multiple species and patients, distinct from known cell types and present in other infections.