Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation
Janine Hochmair, Maxime C. M. van den Oetelaar, Leandre M. Ravatt, Lisa Diez, Lenne J. M. Lemmens, Renata Ponce-Lina, Rithika Sankar, Maximilian Franck, Gesa Nolte, Ekaterina Semenova, Satabdee Mohapatra, Christian Ottmann, Luc Brunsveld, Susanne Wegmann
This study shows that 14-3-3ζ binding to phosphorylated Tau reduces its association with microtubules and inhibits aggregation and condensation.
Communications Biology · Jul 31, 2025Peer-reviewedBiochemistry