Inhomogeneous Tau polymerization, core-shell organization, and seed formation during Tau condensate aging
Maximilian Franck, Abin Biswas, Pin‐Lian Jiang, Martín Fernández-Campo, Satabdee Mohapatra, Rithika Sankar, Alvaro Dominguez‐Baquero, Leandre M. Ravatt, Boglarka Krisztina Nagy-Herczeg, Ozan Emre Kantar, Janine Hochmair, Thorsten Mielke, Lisa Diez, Fan Liu, Michael Krieg, , Susanne Wegmann
This study shows how Tau condensates age into elastic networks with inhomogeneous polymerization and seed formation, providing mechanistic insight into their transition to pathological aggregates.
bioRxiv · Sep 1, 2026 · PreprintBiochemistry