Satabdee Mohapatra

Inhomogeneous Tau polymerization, core-shell organization, and seed formation during Tau condensate aging

This study shows how Tau condensates age into elastic networks with inhomogeneous polymerization and seed formation, providing mechanistic insight into their transition to pathological aggregates.

Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelope

This study shows that increased somatodendritic Tau interacts with nuclear envelope proteins, causing nuclear damage and altering gene expression related to AD and tauopathies.

Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation

This study shows that 14-3-3ζ binding to phosphorylated Tau reduces its association with microtubules and inhibits aggregation and condensation.