Telomerase reverse transcriptase is required for resistance to mycobacterial infection
Darryl JY Han, David M Costa, Geyang Luo, Kathryn Wright, Manitosh Pandey, Denise Wee, Yao Chen, Semih Can Akıncılar, Vinay Tergaonkar, Rajkumar Dorajoo, Guillaume Carissimo, Amit Singhal, Philip M. Elks, Pamela S Ellis, Catarina Martins Henriques, , Stefan H. Oehlers
This study shows that telomerase reverse transcriptase (Tert) is essential for resistance to mycobacterial infection by supporting demand-driven hematopoiesis in zebrafish.
bioRxiv · May 15, 2025 · PreprintImmunology