Darryl JY Han

This study shows that loss of DHCR7 leads to increased 7DHC, which activates IRF3 and impairs anti-bacterial immunity against Mycobacterium marinum in zebrafish.

The paper shows pyrimethamine, an FDA-approved drug, reduces vascular permeability and mycobacterial burden in a zebrafish infection model by inhibiting bacterial dihydrofolate reductase and restoring vascular barrier function.

This study shows that telomerase reverse transcriptase (Tert) is essential for resistance to mycobacterial infection by supporting demand-driven hematopoiesis in zebrafish.