Author

David M Costa

Agency for Science, Technology and Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:zebrafish· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Darryl JY HaniD· 2 shared Stefan H. OehlersiD· 2 shared Amit SinghaliD· 1 shared Bo YaniD· 1 shared Catarina Martins HenriquesiD· 1 shared Denise WeeiD· 1 shared Geyang Luo· 1 shared Guillaume CarissimoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Darryl JY HanORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Loss of 7-Dehydrocholesterol Reductase-mediated cholesterol biosynthesis activates IRF3 and inhibits control of Mycobacterium marinum infection

Xiangyu Sui, Darryl JY Han, David M Costa, Vinitha Jacob, Stefan H. Oehlers

This study shows that loss of DHCR7 leads to increased 7DHC, which activates IRF3 and impairs anti-bacterial immunity against Mycobacterium marinum in zebrafish.

bioRxiv · May 12, 2026 · PreprintImmunology

Telomerase reverse transcriptase is required for resistance to mycobacterial infection

Darryl JY Han, David M Costa, Geyang Luo, Kathryn Wright, Manitosh Pandey, Denise Wee, Yao Chen, Semih Can Akıncılar, Vinay Tergaonkar, Rajkumar Dorajoo, Guillaume Carissimo, Amit Singhal, Philip M. Elks, Pamela S Ellis, Catarina Martins Henriques, , Stefan H. Oehlers

This study shows that telomerase reverse transcriptase (Tert) is essential for resistance to mycobacterial infection by supporting demand-driven hematopoiesis in zebrafish.

bioRxiv · May 15, 2025 · PreprintImmunology