Deep Profiling of Plasma Proteoforms with Engineered Nanoparticles for Top-down Proteomics
Che‐Fan Huang, Michael A. R. Hollas, Aniel Sánchez, Mrittika Bhattacharya, Giang Ho, Ambika Sundaresan, Michael A. Caldwell, Xiaoyan Zhao, Ryan W. Benz, Asim S. Siddiqui, Neil L. Kelleher
This study uses engineered nanoparticles to enrich low-abundant proteins in human plasma, enabling top-down proteomics to detect proteoforms at lower concentrations and expand proteome depth.
Journal of Proteome Research · Sep 23, 2024Peer-reviewedBiochemistry