Author

Michael A. Caldwell

Northwestern UniversityORCID 0000-0002-8636-0706Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Aniel SáncheziD· 3 shared Neil L. KelleheriD· 3 shared Eleonora ForteiD· 2 shared Michael A. R. HollasiD· 2 shared Taojunfeng SuiD· 2 shared Troy D. FisheriD· 2 shared Ambika Sundaresan· 1 shared Andrew LeeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersBiochemistry

Aniel SánchezORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeted Analysis of >1500 Plasma Proteoforms via Individual Ion Mass Spectrometry

Aniel Sánchez, Indira Plá, Katrina N. Peterson, Vincent White, Troy D. Fisher, Michael A. R. Hollas, Taojunfeng Su, Nhat Hoang Van Le, Claire Harrington, Paolo Cravedi, David N. Assis, Paola A. Barrios, Therese Elaine Banea, Daniela P. Ladner, Eleonora Forte, , Neil L. Kelleher

This paper introduces two plasma proteoform panels, PPA 526 and PPA 1514, using Individual Ion Mass Spectrometry to quantify proteoforms in human plasma with high reproducibility and disease discrimination capability.

bioRxiv · May 31, 2026 · PreprintBiochemistry

Next-Generation Protein Sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6

Kenneth A. Skinner, Troy D. Fisher, Andrew Lee, Taojunfeng Su, Eleonora Forte, Aniel Sánchez, Michael A. Caldwell, Neil L. Kelleher

This study compares single-molecule protein sequencing and individual ion mass spectrometry to analyze IL-6 proteoforms, showing combined coverage of 52% of the sequence.

Analytical and Bioanalytical Chemistry · Oct 1, 2025Peer-reviewedBiochemistry

Deep Profiling of Plasma Proteoforms with Engineered Nanoparticles for Top-down Proteomics

Che‐Fan Huang, Michael A. R. Hollas, Aniel Sánchez, Mrittika Bhattacharya, Giang Ho, Ambika Sundaresan, Michael A. Caldwell, Xiaoyan Zhao, Ryan W. Benz, Asim S. Siddiqui, Neil L. Kelleher

This study uses engineered nanoparticles to enrich low-abundant proteins in human plasma, enabling top-down proteomics to detect proteoforms at lower concentrations and expand proteome depth.

Journal of Proteome Research · Sep 23, 2024Peer-reviewedBiochemistry