Che‐Fan Huang

This study uses I2MS to analyze phosphorylation states of catenins in HEK cells, revealing their regulation by actomyosin contractility and identifying a phospho-code model for mechano-transduction.

This study shows replication stress reduces CENP-A nucleosome stability in S phase by disrupting ATRX and DAXX function, leading to centromere instability.

The paper shows that α-catenin phosphorylation during mitosis prevents apical rounding and epithelial barrier leak by strengthening cell-cell interactions.

This study uses top-down proteomics to identify plasma proteoform signatures that distinguish stages of liver cirrhosis progression.

This study uses engineered nanoparticles to enrich low-abundant proteins in human plasma, enabling top-down proteomics to detect proteoforms at lower concentrations and expand proteome depth.