ImmunologybioRxivPreprint
The ubiquitin E3 ligase Huwe1 facilitates viral and self RNA sensing by RIG-I-like receptors
Timo Oosenbrug, Dennis Gravekamp, Adán Pinto-Fernández…·Annemarthe G. van der Veen
This study shows Huwe1 is essential for RIG-I-like receptor-mediated type I and III IFN induction by ubiquitinating key pathway components like TRAF5.